Small molecule
Small molecule that activates or enhances reelin pathway signaling
Reelin-Based Neuroscience Therapeutics
Restoring the Brain's Capacity to Adapt and Repair
Avendia Therapeutics is developing a new generation of medicines built around reelin, a powerful regulator of synaptic function, plasticity, and brain health.
One pathway. Multiple therapeutic opportunities.
reelin-based neuroscience
Harnessing reelin biology to restore synaptic function.
One pathway
One pathway. Multiple therapeutic opportunities.
Reelin sits upstream of multiple cellular processes essential for healthy brain function, including NMDA receptor activity, AMPA receptor trafficking, dendritic spine maturation, synaptic plasticity, and neurogenesis.
Rather than targeting a single downstream consequence of disease, Avendia is developing therapies designed to restore the coordinated signaling needed for functional neural circuits.
A focused reelin platform
Harnessing reelin biology to restore synaptic function.
Our therapeutic platform focuses on small-molecule and gene therapy approaches designed to harness reelin biology across neurological and neuropsychiatric diseases.
Gene therapy
Gene therapy designed to provide sustained reelin activity in targeted brain regions
The science: how it works
Reelin strengthens synapses and supports cognition
Reelin activates ApoER2/VLDLR receptors, engaging Dab1 and downstream signaling that enhances synaptic function and supports learning, memory, and circuit balance.
Stronger connections
Clearer signaling
Better balance
Healthy adaptation
New brain cells
See how reelin worksAvendia Therapeutics